Leon Hooftman Selected Research

tosedostat

10/2010	Phase I/II clinical study of Tosedostat, an inhibitor of aminopeptidases, in patients with acute myeloid leukemia and myelodysplasia.
8/2009	A first-in-man phase i and pharmacokinetic study on CHR-2797 (Tosedostat), an inhibitor of M1 aminopeptidases, in patients with advanced solid tumors.

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Leon Hooftman Research Topics

Disease

4	Neoplasms (Cancer) 01/2020 - 08/2009
3	Thrombocytopenia (Thrombopenia) 05/2012 - 08/2009
2	Fatigue 07/2013 - 05/2012
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2020
1	Leukocytosis (Pleocytosis) 01/2017
1	Lymphocytosis 01/2017
1	Multiple Myeloma 07/2015
1	Constipation 07/2013
1	Exanthema (Rash) 07/2013
1	Anorexia 07/2013
1	Nausea 07/2013
1	Pancreatic Neoplasms (Pancreatic Cancer) 05/2012
1	Atrial Fibrillation 05/2012
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 10/2010
1	Hematologic Neoplasms (Hematological Malignancy) 10/2010
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2010
1	Anemia 08/2009
1	Vomiting 08/2009
1	Dizziness (Lightheadedness) 08/2009
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/2005

Drug/Important Bio-Agent (IBA)

2	Pharmaceutical PreparationsIBA 07/2013 - 08/2009
2	Histone Deacetylase InhibitorsIBA 07/2013 - 05/2012
2	CreatinineIBA 07/2013 - 05/2012
2	tosedostatIBA 10/2010 - 08/2009
2	AminopeptidasesIBA 10/2010 - 08/2009
1	Carboplatin (JM8)FDA LinkGeneric 01/2020
1	VaccinesIBA 01/2020
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2020
1	balixafortideIBA 01/2017
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2017
1	CHR 2845IBA 07/2013
1	Histones (Histone)IBA 05/2012
1	2- (6- (((6- fluoroquinolin- 2- yl)methyl)amino)bicyclo(3.1.0)hex- 3- yl)- N- hydroxypyrimidine- 5- carboxamideIBA 05/2012
1	AT 130IBA 10/2010
1	Cytarabine (Cytosar-U)FDA LinkGeneric 09/2005

Therapy/Procedure

2	Therapeutics 07/2015 - 08/2009
1	Drug Therapy (Chemotherapy) 01/2020